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333 Therefore, integrating microbiota management (including dietary guidance, probiotics/prebiotics, selective intestinal decontamination) into the full-course treatment of liver fibrosis/cirrhosis is expected to synergize with existing therapies from multiple dimensions such as reducing pathogenic signal output, enhancing the gut barrier, and regulating immunity, delaying disease progression and improving patient quality of life

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NMR Structural Resolution of FOXO4-DRI/p53TAD2 Complex (Nature Communications, 2025) Disordered-to-Ordered Complex Formation: Structural Basis of FOXO4-DRI’s Senolytic Mechanism A landmark structural study published in Nature Communications (2025) resolved the solution NMR structural models of the p53 transactivation domain (TAD2) in complex with the FOXO4 forkhead domain and with FOXO4-DRI